Sr Staff Mechanical Engineer
Role Overview
We are seeking a Senior Staff Mechanical Engineer to design, build, and test our next-generation automated wet-lab instruments. Based primarily on-site in Wilsonville, OR with partial remote flexibility, this role requires occasional travel to Twist in South San Francisco, CA and to vendor locations.
Key Skills for This Role
Full Job Posting
Summary
We are seeking a Senior Staff Mechanical Engineer to design, build, and test our next-generation automated wet-lab instruments. Based primarily on-site in Wilsonville, OR with partial remote flexibility, this role requires occasional travel to Twist in South San Francisco, CA and to vendor locations.
Responsibilities:
- Use SolidWorks to design multiple instruments that integrate liquid handling, consumable handling, imaging & robotics that meet or exceed System & Hardware requirements
- Manage and use SolidWorks AI Agents to create new hardware designs leveraging parts & assemblies already in Twist’s PDM environment
- Specify all hardware (off-the-shelf and custom) for the instruments
- Work with other team members to develop and refine requirements
- Perform tolerance analysis as needed
- Support contract manufacturers and vendors as the Mechanical Technical Lead for your designs
- Work with other team members to execute and support Factory and Site Acceptance Testing
- Compile content and hold multiple design reviews as needed
- Use SolidWorks to design & build test fixtures as needed to de-risk concept features or test sub-systems
- Support Process Systems Engineers as needed during Concept Development and all other project phases
- Provide system fluidics and electrical design documentation
- Build, debug, calibrate, and verify the instruments with help from technicians and Process System Engineers
- Create full models, part files, part drawings, assembly drawings & a BOM for the System
- Maintain full design control and release via 3D- Experience (Dassault Systèmes)
- Order & track parts for system builds
- Provide updated designs for obsolete parts
- Lead hardware design for next-generation custom instrumentation, from concept and feasibility through post-production support.
- Provide concept architectures for Roadmap development
Required Skills:
- 12+ years of experience as a Senior Mechanical Engineer(or higher) and a 4-year degree in mechanical engineering, or 8 years of experience as a Senior Mechanical Engineer (or higher), with a graduate degree in mechanical engineering
- Expert in SolidWorks, with a proven record of delivering end-to-end design packages, complete engineering documentation, and fabrication-ready deliverables.
- Lead Mechanical Engineer of at least 2 benchtop or larger instruments that went into Production
- Strong experience with robotics/mechatronics and specifying electronic devices
- Extensive experience designing hardware for fluidics systems, including custom manifolds and integration of pumps, valves, sensors, regulators, etc.
- Proven track record of collaborating with cross-functional teams—including engineers, scientists, and project managers—across the entire project lifecycle, from initial concept to post-release monitoring
- Experience managing a CAD PDM system
- Excellent communication and writing skills, and the ability to work in a fast-paced team environment
- Very strong documentation skills
- Comfortable working with evolving requirements and a dynamic work environment driving hardware designs for multiple projects
- Proven ability to perform System Integration
- Proven ability to perform Systems Testing, including Factory/Site Acceptance Testing
Additional Bonus Skills:
- Proficiency in 3DExperience
- Experience with mechanical design for optical systems
- In-depth knowledge and use of machine shop tools (band saws, Mill, drill press, sanders)
- Experience performing electrical and electronics troubleshooting
- Experience with Altium, Lucid, or other software tools that can be used to create wiring or plumbing diagrams
- Experience in specifying device control
- Experience compiling and releasing QA documentation
- Experience as an Instrument Technical Lead or Instrumentation Systems Engineer
About Twist Bioscience
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
Requirements
- 12+ years of experience as a Senior Mechanical Engineer(or higher) and a 4-year degree in mechanical engineering, or 8 years of experience as a Senior Mechanical Engineer (or higher), with a graduate degree in mechanical engineering
- Expert in SolidWorks, with a proven record of delivering end-to-end design packages, complete engineering documentation, and fabrication-ready deliverables.
- Lead Mechanical Engineer of at least 2 benchtop or larger instruments that went into Production
- Strong experience with robotics/mechatronics and specifying electronic devices
- Extensive experience designing hardware for fluidics systems, including custom manifolds and integration of pumps, valves, sensors, regulators, etc.
- Proven track record of collaborating with cross-functional teams—including engineers, scientists, and project managers—across the entire project lifecycle, from initial concept to post-release monitoring
- Experience managing a CAD PDM system
- Excellent communication and writing skills, and the ability to work in a fast-paced team environment
- Very strong documentation skills
- Comfortable working with evolving requirements and a dynamic work environment driving hardware designs for multiple projects
- Proven ability to perform System Integration
- Proven ability to perform Systems Testing, including Factory/Site Acceptance Testing
- Proficiency in 3DExperience
- Experience with mechanical design for optical systems
- In-depth knowledge and use of machine shop tools (band saws, Mill, drill press, sanders)
- Experience performing electrical and electronics troubleshooting
- Experience with Altium, Lucid, or other software tools that can be used to create wiring or plumbing diagrams
- Experience in specifying device control
- Experience compiling and releasing QA documentation
- Experience as an Instrument Technical Lead or Instrumentation Systems Engineer
About Twist Bioscience
Public biotechnology company serving life-science researchers with synthetic DNA, sequencing, and biopharma discovery tools.
Visit company websiteJobs and hiring trendsApply for this job in 1 click
Skip the repetitive application forms
Install the Base Career Chrome Extension and autofill job applications across major job boards with your profile.
Trusted by over 500,000 job seekers on Base Career
More from this employer
More jobs at Twist Bioscience
Account Manager, DNA Synthesis - SouthEast
, USA
The Account Manager is responsible for delivering revenue and driving growth in their territory for Twist Bioscience gene synthesis products. This role is accountable for delivering accurate revenue forecasts throughout
Master Data Governance Office Lead
South San Francisco, USA
Master Data Governance Office Lead (Hybrid in South San Francisco, CA) Summary Reporting directly to the Director of Business Intelligence, the SAP Master Data Governance (MDG) Lead will provide business processes expert
Sr Staff Program Manager, MES Custom Software Development Transformation
South San Francisco, USA
Sr Staff Program Manager, MES Custom Software Development Transformation (Hybrid in South San Francisco, CA or Wilsonville, OR) Summary Twist Bioscience is embarking on a strategic transformation of its Manufacturing Exe
Director, Security and Compliance
South San Francisco, USA
Director, Security and Compliance Job Overview The Director of Security and Compliance is a strategic, highly technical leader responsible for designing, scaling, and overseeing our global information security and regula
Shipping Coordinator
South San Francisco, USA
Twist Bioscience is looking for an individual that is highly motivated, collaborative, takes pride in their work, and great attention to detail. This position will play a critical role in forming a best in class Shipping
Manager, Quality Management Systems
South San Francisco, USA
We are looking for an experienced Manager of Quality Management Systems to build, maintain, and improve our ISO 13485-certified QMS. In this role, you will own our internal and external audit program and our quality trai
Sr. Financial Analyst, Corporate FPA
South San Francisco, USA
We are looking for a Senior Financial Analyst to join our Corporate FP&A team, reporting directly to the Senior Director of FP&A. This role sits at the center of how Twist plans and reports. You will build the models and
Account Manager, DNA Synthesis - SouthEast
, USA
Master Data Governance Office Lead
South San Francisco, USA
Sr Staff Program Manager, MES Custom Software Development Transformation
South San Francisco, USA
Director, Security and Compliance
South San Francisco, USA
Shipping Coordinator
South San Francisco, USA
Manager, Quality Management Systems
South San Francisco, USA
Sr. Financial Analyst, Corporate FPA
South San Francisco, USA
QA Associate II
Portland, USA