Sr. Scientist, Antibody Engineering
Full Job Posting
Position Responsibilities
Design, execute, and troubleshoot antibody discovery campaigns using phage display, including library screening, selection strategy development, clone recovery, and sequence analysis.
Optimizing antibody leads with display-based technologies, including affinity maturation, specificity engineering, and developability-focused screening.
Express and purify recombinant antibodies, antibody fragments, antigens, and related proteins using appropriate chromatographic methods.
Characterize binding, specificity, affinity, stability, purity, and other biochemical or biophysical properties of antibody candidates.
Analyze and interpret experimental data, maintain clear records, and communicate results and recommendations to project teams.
Collaborate cross-functionally with protein sciences, structural biology, assay biology, and therapeutic-area teams to advance discovery programs.
Evaluate and implement new technologies, workflows, and automation opportunities that strengthen antibody discovery and optimization capabilities.
Provide scientific leadership for project workstreams and mentor junior colleagues as appropriate.
Candidate Requirements
- Ph.D. in biochemistry, molecular biology, protein engineering, biophysics, or a related life-science field with relevant industry or postdoctoral experience; or an M.S./B.S. with commensurate relevant experience. Level will be determined by qualifications and experience.
- Hands on experience with antibody discovery and optimization using phage display is required, yeast display experience is highly preferred.
- Working knowledge of antibody formats, library design or screening principles, molecular biology, and sequence-based clone assessment.
- Experience with protein purification techniques such as affinity, ion-exchange, and size-exclusion chromatography.
- Ability to characterize proteins and antibodies using biochemical and biophysical methods such as SPR, BLI, ELISA, and flow cytometry.
- Strong experimental design, problem-solving, documentation, communication, and teamwork skills.
- Experience in applying structural insights to antibody design and optimization is preferred.
- Additional information
- Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Additional information
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Preferred Qualifications
- Hands on experience with antibody discovery and optimization using phage display is required, yeast display experience is highly preferred.
- Experience in applying structural insights to antibody design and optimization is preferred.
About Scholar Rock
Clinical-stage biopharmaceutical company developing selective medicines for people with serious neuromuscular diseases.
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