Senior Director, Disease Biology

Requirements

• PhD in neuroscience, immunology, cell biology, genetics, pharmacology, or a related field.
• Extensive experience leading target discovery in neurodegeneration, from disease biology and human genetics through target validation.
• Track record advancing programs from validated target through lead optimization, in vivo proof of concept, and IND enabling studies, including building or partnering with the supporting toxicology and pharmacokinetics capabilities.
• Deep expertise developing or applying advanced 3D cellular models of neurodegenerative disease.
• Proven people leadership, including mentoring established scientific teams, building new teams and capabilities from the ground up, and running matrixed, cross functional programs.
• Strong partnership with computational biology and machine learning teams, applying causal modeling and human genetic data to target discovery and validation.
• Experience in a fast paced biotech or nonprofit research institute environment.
• Ability to work onsite in our Palo Alto office a minimum of four days per week.
• Preferred Qualifications
• Direct experience in Alzheimer's disease drug discovery.
• Hands-on experience generating and validating animal models of Alzheimer’s disease, including genetic risk variant models such as APOE4 and TREM2.
• Experience integrating computational and machine learning driven target prioritization into discovery strategy.
• Experience partnering with high throughput biology teams.
• The base salary range for this position is $263,500 to $325,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.