Senior Scientist, Protein Sciences
Role Overview
Strand is seeking a highly motivated and innovative Senior Scientist of Protein Sciences to join our Platform Enabling Technologies team.
This founding role will establish and lead protein science capabilities that enable the discovery, engineering, and validation of protein payloads, binders, and reagents for Strand’s programmable RNA medicines.
Reporting to the Associate Director of Platform Enabling Technologies, the ideal candidate combines deep expertise in nanobody or antibody engineering, computational protein design, high-throughput protein purification and characterization, and enthusiasm for building new scientific functions while remaining active on the bench.
This role integrates experimental protein sciences with AI-enabled design to discover and optimize antibodies, nanobodies, and other therapeutic proteins. Working closely with our computational biology, RNA biology, delivery, and translational teams, the scientist will define protein design criteria, lead experimental validation, and connect molecular attributes, including expression, folding, secretion, stability, activity, and developability as recombinant protein and following RNA delivery.
Full Job Posting
Qualifications
- PhD with 2-5 years of experience, or B.S/M.S. with 7-10 years of experience in Biochemical Engineering, Biotechnology, Biochemistry, Molecular Biology, or a related scientific discipline.
- Demonstrated expertise in nanobody or antibody discovery and engineering including library design, screening and production, humanization, affinity maturation, and experimental validation.
- Demonstrated expertise in high-throughput recombinant protein expression, purification, and characterization from mammalian, yeast, and bacterial systems including cell culture, chromatography-based separations, and affinity/developability assays.
- Proven track record of developing biologics as therapeutics and delivering on projects to enable programs to progress toward IND submissions.
- Experience with advanced protein characterizations methods such as LC-MS, SEC-MALS, and SPR/BLI.
- Strong understanding of ML/AI enabled protein design methodologies and the experimental validation of resulting designs. Direct, hands-on experience in deploying methods preferred.
- Strong understanding of protein structure-function relationships, sequence–function relationships, and principles governing properties related to successful drug development including protein stability, activity, specificity, immunogenicity, and developability.
- Experience integrating yeast or phage display, high-throughput screening and computational library design.
- Experience analyzing complex experimental datasets and using quantitative approaches to guide subsequent protein engineering cycles.
- Experience with protein conjugation and downstream purification and characterization a plus but not required.
- Experience with building laboratory capabilities, managing external partners, or translating research workflows into development preferred but not required.
- Experience with RNA biology, RNA delivery, lipid nanoparticles, or related delivery technologies is a strong plus, but not required for candidates with exceptional protein engineering expertise.
- Ability to work effectively in a highly interdisciplinary environment and collaborate with scientists across RNA biology, LNP formulation, cell biology, computational biology, and analytical sciences.
- Strong track record of scientific communication, including presenting complex data and conclusions to multidisciplinary teams.
- Experience mentoring junior scientists and contributing to experimental strategy and technical direction.
- A track record of scientific contributions through peer-reviewed publications, patents, or other evidence of technical innovation.
- Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand’s goals.
- Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.
- Job Type: Full-time
- Salary: $132,000 - $142,000 annually plus bonus and equity incentives
- Pay Transparency Base Salary Range$132,000—$142,000 USD
Preferred Qualifications
- Strong understanding of ML/AI enabled protein design methodologies and the experimental validation of resulting designs. Direct, hands-on experience in deploying methods preferred.
- Experience with protein conjugation and downstream purification and characterization a plus but not required.
- Experience with building laboratory capabilities, managing external partners, or translating research workflows into development preferred but not required.
- Salary: $132,000 - $142,000 annually plus bonus and equity incentives
About Strand Therapeutics
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