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Scientist I, Display Technologies
BigHat Biosciences
San Mateo, USA
Full-time
Entry · 2+ years experience
Onsite
USD 120000-145000 yearly / year
Discovered 1 months ago
PCRLIMSELISANGS
Key Skills for This Role
PCRLIMSELISANGS
Full Job Posting
Key Responsibilities
- Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
- Lead in the construction and QC of phage display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
- Execute standard phage display selections to engineer antibodies with desired therapeutic properties.
- Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
- Analyze selection results and contribute to discussions on next steps and future experimental design.
- Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
- Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
- Present experimental plans and results during regular meetings with manager and science teams.
- Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners.
- Maintain thorough records using LIMS and electronic notebooks.
Skills Knowledge and Expertise
- Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related field, with up to 2 years of industry research experience; or an M.S. in a related field with 6+ years of relevant industry research experience.
- Experience with display technologies, including library design and selection strategies.
- Knowledge of antibody biology and protein expression.
- Strength in general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
- Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.
- Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
- Effective time management and clear written and verbal communication skills.
- Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
- Scientific track record and publication record.
- Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.
About BigHat Biosciences
Biotechnology98 employeesFounded 2019
Private biotechnology company designing safer, more effective antibody therapies with machine learning and synthetic biology for patients.
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